WebAug 29, 2005 · Mouse enteric defensins (cryptdins) are produced and secreted constitutively but are overexpressed in instances of infection and/or inflammation. Our … WebMouse Paneth cell α-defensins, termed cryptdins, are secreted into the intestinal lumen, have microbicidal activity, and contribute to intestinal innate immunity. Among them, …

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WebStudies of single crypts show that cryptdins secreted by Paneth cells are effective at withstanding ex vivo infectious challenge, even when diluted by a factor of 2.5 × 10 6 relative to the ... WebAug 15, 1992 · Five intestinal defensins, termed cryptdins 1-5, have been purified from mouse small bowel, sequenced, and localized to the epithelium by immunohistochemistry. Although identified as members of the defensin peptide family by peptide sequencing, enteric defensins are novel in that four cryptdins have amino termini which are three to … cabas onthego

Nod2-Dependent Regulation of Innate and Adaptive Immunity in …

WebFeb 4, 2005 · Nod2 is required for the expression of cryptdins and for protection against intracellular bacterial infection in the intestine. ( A ) Wild-type and Nod2 –/– mice (8 to 12 weeks old) were infected with 3 × 10 3 L. monocytogenes (strain 10403S) intravenously, and the number of bacteria in the liver and the spleen was counted 24 and 48 hours ... WebThe azurophilic granules of human neutrophils contain four α-defensins called human neutrophil peptides (HNPs 1-4). HNPs are tridisulfide-linked antimicrobial peptides involved in the intracellular killing of organisms phagocytosed by neutrophils. WebWe have previously shown that Hes1 is expressed both in putative epithelial stem cells just above Paneth cells and in the crypt base columnar cells between Paneth cells, while Hes1 is completely absent in Paneth cells. This study was undertaken to clarify the role cabasse sloop 2