Kashin beck disease gwas
WebbKashin-Beck disease (KBD) is a chronic osteochondropathy, the pathogenesis of which remains elusive. The aim of this study was to identify susceptibility genes for KBD by … Webb6 jan. 2024 · Kashin-Beck disease (KBD) is a chronic osteochondropathy. The pathogenesis of growth and development failure of hand of KBD remains elusive now.
Kashin beck disease gwas
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WebbDuring the past several decades, etiological and geochemical studies tend to link the Kaschin-Beck Disease (KBD) to the deficiency of some specific trace elements (e.g., selenium and iodine) in the environment; however the link has been proven inconclusive. In this work, we have investigated the rel … Webb9 okt. 2014 · Kashin-Beck disease (KBD) is a chronic osteochondropathy, the pathogenesis of which remains elusive. The aim of this study was to identify susceptibility genes for KBD by conducting a 2-stage genome-wide association study (GWAS). Methods
Webb13 okt. 2015 · GWAS meta-analysis identified six candidate genes with pleiotropic effects, including PDGFD, SOX5, DPYD, CTR9, SPP1, and COL4A1. GO analysis identified 16 significant GO shared by KBD and the... Webb23 apr. 2016 · Kashin-Beck disease (KBD) is an endemic osteochondropathy (Stone 2009 ), characterized by cartilage degeneration, cartilage matrix degradation, …
Webb15 dec. 2014 · Kashin-Beck disease (KBD) is a serious osteoarthropathia, mainly characterized by excessive chondrocyte necrosis and apoptosis. The molecular … Webb1 jan. 2015 · Kashin-Beck disease (KBD) is a chronic osteochondropathy, ... Results The GWAS identified significant association (P = 1.58 × 10(-8) ) between KBD and a novel locus, ITPR2 SNP rs10842750. The replication study showed significant associations with KBD at 9 ITPR2 SNPs, including rs10842750 ...
Webb9 juli 2012 · Kashin–Beck disease (KBD) is characterized by chondrocytic necrosis and apoptosis, cartilage degeneration and matrix degradation ... miRNA–mRNA target databases, GWAS databases, KEGG and so on. IPA is easy to operate and offers high-quality diagrams of pathways and networks that contain much information using a visual …
WebbSelenium deficiency causes Keshan disease (cardiomyopathy) and Kashin-Beck disease (osteoarthritis) and has been linked to oxidative stress, inflammation, ... we conducted a two-stage genome-wide association study (GWAS) by using the data from two cohorts to examine the effects of genetic variation on serum selenium concentrations. 2. Subjects ... skf reliability systemsWebbThis study aims to uncover insight into the epigenetic modifications for Kashin-Beck disease (KBD) by integrating genome-wide association studies (GWAS), … skf remote connectWebb3 maj 2024 · Kashin-Beck Disease (KBD) is a type of endemic, chronic, and disabling osteoarthropathy with high disability. KBD is also named as endemic … skf radial wellendichtring cadWebb22 aug. 2016 · Kashin-Beck disease (KBD) is a chronic osteoarthropathy, which manifests as joint deformities and growth retardation. Only a few genetic studies of … swagelok youtube channelWebbKashin–Beck disease ( KBD) is a chronic, endemic type of osteochondropathy (disease of the bone) that is mainly distributed from northeastern to southwestern China, including 15 provinces. [1] As of … s k freight lines pvt. limitedWebb1 nov. 2011 · To evaluate the performance of SWGDT, a real GWAS dataset of Kashin-Beck disease (KBD) was analyzed. Immunohistochemisty was also performed to validate the relevance of identified gene with KBD. skf recifeWebb6 jan. 2024 · Kashin-Beck disease (KBD) is a chronic, endemic osteochondrosis 1,2. KBD is usually first occurred in children aged 3–12 years. With age, KBD patients … swagelok wisconsin